Does amitriptyline cause QT prolongation?
TCAs and SNRIs have also been shown to prolong the QT interval to varying degrees.
Certain TCAs (eg, amitriptyline, maprotiline) may lead to QT prolongation, although others do not (eg, clomipramine).
The risk of QT prolongation is similarly low for the SNRIs, including duloxetine and desvenlafaxine..
Does hypokalemia cause QT prolongation?
The most dangerous aspect of hypokalemia is the risk of ECG changes (QT prolongation, appearance of U waves that may mimic atrial flutter, T-wave flattening, or ST-segment depression) resulting in potentially lethal cardiac dysrhythmia.
What medications cause prolonged QT syndrome?
Causes of acquired long QT syndrome Certain common antibiotics, such as erythromycin (Eryc, Erythrocin, others), azithromycin (Zithromax, Zmax) and others. Certain antifungal medications taken by mouth used to treat yeast infections. Diuretics that cause an electrolyte imbalance (low potassium, most commonly)
What medications should be avoided with long QT syndrome?
Table 1Drugs to be avoided in patients with c-long QT syndromeAnti-psychoticClozapine, Ziprasidone, Thioridazine, Risperidone, Mesoridazine, Quetiapine, Haloperidol, Pimozide, Amisulpride, Sertindole, Sertindole, Iloperidone, Paliperidone, ChlorpromazineAnti-viralFoscarnet, Ritonavir, Atazanavir47 more rows•Apr 26, 2013
Which antidepressants cause QT prolongation?
Selective Serotonin Reuptake Inhibitors (SSRIs): There are published case reports linking all six currently available SSRIs (fluvoxamine, fluoxetine, paroxetine, sertraline, citalopram, and escitalopram) to QTc prolongation.
What causes QT prolongation?
There are many factors that predispose to QT prolongation including, e.g. age, female gender, left ventricular hyperthrophy, heart failure, myocardial ischaemia, hypertension, diabetes mellitus, increased thyroid hormone concentrations, elevated serum cholesterol, high body mass index, slow heart rate and electrolyte …